St. Louis Entrepreneurial
Resource Ecosystem
TechArtista
TechArtista is a diverse, city-wide, ecosystem of coworking spaces made up of creatives, business types, and non-profit professionals. Membership gives you access to great coworking and meeting locations across the city, plus an extensive list of amenities that foster work and play.
Address:
4818 Washington Blvd, St. Louis, MO 63108; 401 Pine Street, St. Louis, MO 63102; 725 Kingsland Avenue, University City, MO 63130
Email:
info@techartista.orgWebsite:
https://www.techartista.org/Spark
Located in PWC Pennant Building, Spark is a collaborative workspace providing local entrepreneurs and startups an affordable and efficient way to grow their businesses and teams.
Address:
6 Cardinal Way Suite 900, St. Louis, MO 63102
Email:
info@spark-stl.comWebsite:
https://sparkcoworking.com/st-louis/InvestMidwest
InvestMidwest highlights startups with the most promise in the Midwest region, or seeking to use the Midwest as a launching pad. The conference provides an ideal opportunity for entrepreneurs to raise capital and all attendees to make new connections.
Website:
https://www.investmidwest.org/Harris-Stowe State University
Harris-Stowe State University (HSSU) is home to the Anheuser-Busch School of Business and the Center for Innovation and Entrepreneurship (CIE). CIE is committed to fostering creativity and facilitating the realization of groundbreaking ideas in both individuals and organizations. Their mission is to expand opportunities, cultivate highly skilled and knowledgeable individuals, advance research, and provide exceptional programs.
Wedge Innovation Center
The Wedge is a private coworking and events workspace in the heart of Alton, Illinois. They feature flexible membership options and offer a $5 option on Fridays for potential new members to try the space.
Missouri Small Business Development Center
Southeast Missouri State University (SEMO) is a comprehensive university, recognized for excellence in education, research, engagement, and creativity. The Missouri Small Business Development Center (SBDC) at SEMO provides no-cost coaching and support to small businesses across the Southeast region.
Address:
One University Plaza, Cape Girardeau, MO 63701
Email:
jpallesen@semo.eduWebsite:
https://semo.edu/economic-workforce/business-development/UMSL Entrepreneurship and Innovation Center
UMSL provides accessible, innovative, and research-informed, public education that impacts lives. They advance real-world, relevant, and impactful research. UMSL partners with alumni and business leaders to drive regional economic development. UMSL is home to the Entrepreneurship and Innovation Center which champions a vibrant and sustainable innovation ecosystem through grit, connection and a growth mindset.
Address:
35 Performance Drive, St. Louis, MO 63121
Email:
scottmorris@mail.umsl.eduWebsite:
https://www.umsl.edu/business/departments/eic/index.htmlSaint Louis University Chaifetz Center for Entrepreneurship
Saint Louis University is the home of one of the first business schools in the American West, Chaifetz School of Business, as well as the Chaifetz Center for Entrepreneurship. The school delivers a world-class education, develops and delivers innovative programs, provides networking opportunities, as well as programs for high school and college students. The Saint Louis University New Venture Accelerator (NVA) allows SLU founders to launch their entrepreneurial journeys with access to funding, resources, advisors and guidance to propel their ideas to reality.
Address:
3674 Lindell Blvd, St. Louis, MO 63108
Email:
ecenter@slu.eduWebsite:
https://www.slu.edu/business/centers/center-for-entrepreneurship/index.phpWashington Univeristy Skandalaris Center
WashU's Olin Business school is part of the entrepreneurial ecosystem in St. Louis as well as Silicon Valley, New York City and Tel Aviv. It is also home to the Skandalaris Center for Interdisciplinary Innovation and Entrepreneurship, which supports founders and aspiring entrepreneurs at all stages.
Address:
6465 Forsyth Blvd, Mallinckrodt Center Room 128 St. Louis, MO 63105
Email:
sc@wustl.eduWebsite:
https://skandalaris.wustl.edu/Cortex Square One
Cortex's Square One series of training help entrepreneurs and innovators build basic business skills, and strengthen the skills their investors or employers most request.
Address:
4240 Duncan Avenue Suite 200 St. Louis, MO 63110
Email:
info@cortexstl.orgWebsite:
https://www.cortexstl.org/learnSTLP
Describes themselves as the one stop shop for expanding business in St. Louis and its Counties
Address:
120 South Central Avenue, Suite 200 St. Louis, MO 63105
Email:
Rlward@stlpartnrship.comWebsite:
https://stlpartnership.com/who-we-are/board-of-directors/39 North
39 North is a vibrant, diverse community working in proximity with one another, sharing ideas, networks, and cutting-edge equipment and facilities for agtech companies. The district is anchored by Bayer Crop Science and the Danforth Plant Science Center, and facilities include Helix Center BioTech Incubator and the BRDG Park.
Address:
1001 N Warson Rd Suite 201, St. Louis, MO 63132
Email:
rishi@39northstl.orgWebsite:
https://39northstl.org/Cortex Innovation District
The Cortex Innovation District, celebrated globally for innovation, creativity, and entrepreneurship, empowers a diversity of communities by providing the resources needed to shape the future. Home to startups, R&D teams, manufacturers, nonprofits, and creators of all kinds, Cortex is where technology, art, and enterprise converge to grow and connect.
Address:
4240 Duncan Avenue Suite 200 St. Louis, MO 63110
Email:
info@cortexstl.orgWebsite:
https://www.cortexstl.org/BRDG Park
Located on the campus of the Danforth Plant Science Center in St. Louis, Missouri, BRDG Park serves as a vital resource for both early to mid-stage startups, and for international companies that have established their North American headquarters in our thriving ecosystem.
Arch Grants
Arch Grants is dedicated to contributing and boosting the startup ecosystem in St. Louis. They help early entrepreneurs grow by forging connections between Founders and potential investors, customers and talent. They award up to $75,000 per company through their annual global Startup Competition.
Address:
2315 Locust Street Suite 2B St. Louis, MO 63103
Email:
info@archgrants.orgWebsite:
https://archgrants.org/T-REX
T-REX is a non-profit innovation and entrepreneur development center dedicated to strengthening the economic vitality of St. Louis, one startup at a time. It is a co-working space, technology incubator, and entrepreneur resource center.
Address:
911 Washington Avenue Floor 5, St. Louis, MO 63101
Email:
info@downtowntrex.orgWebsite:
https://downtowntrex.org/The BALSA Foundation
The BALSA Foundation’s mission is to promote social equity and prosperity in the St. Louis region by empowering first-time entrepreneurs to start and grow their businesses. They offer cash grants, mentorship, and donations of professional services.
Address:
4818 Washington Ave., St. Louis, MO 63108
Email:
contact@balsafoundation.orgWebsite:
https://www.balsafoundation.org/The Helix Center
Biotech incubator Campus that provides the resources needed to accelerate the growth of any startup. Offers wet labs, dry labs, office space, financing and collaboration.
Address:
1100 Corporate Square, Creve Coeur, MO 63132
Email:
mdavies@biogenerator.orgWebsite:
https://stlpartnership.com/who-we-are/our-teams/innovation-entrepreneurship/business-centers/helix-center/IEEE
IEEE (Institute of Electrical and Electronics Engineers) is the world's largest technical professional organization, advancing technology for the benefit of humanity through education, standards, and innovation in electrical, electronic, and computing fields.
StartupBlink
StartupBlink collaborates with hundreds of governments and global development organizations around the world on a variety of projects related to entrepreneurship, innovation, and startup ecosystem growth.
STL Startup Week
Each year, STLSW brings together thousands of founders, small business owners, investors, industry experts, and community leaders to spark new ideas, foster meaningful connections, promote shared learning, and celebrate success. The week-long programming features inspiring talks, hands-on workshops, dynamic panel discussions, competitions, networking events, meetups, and more.
CIC
Founded in 1999, CIC today manages 1.5M square feet of workspace, laboratories, and event space across North America, Europe, and Asia. Additionally, CIC develops bespoke programming, builds and enables industry clusters, and provides world-class district consulting—all focused on advancing innovation.
Address:
20 S Sarah St., St. Louis, MO 631084220 Duncan Ave., St. Louis, MO 631104240 Duncan Ave., St. Louis, MO 63110
Email:
rowe@cic-health.comWebsite:
https://cic.com/st-louis/U.S Small Business Administration
Created in 1953, the U.S. Small Business Administration (SBA) continues to help small business owners and entrepreneurs pursue the American dream. SBA is the only cabinet-level federal agency fully dedicated to small business and provides counseling, capital, and contracting expertise as the nation’s only go-to resource and voice for small businesses. The St. Louis office provides help with SBA services including funding programs, counseling, federal contracting certifications, and disaster recovery.
Address:
Plant Growth Chamber, 1222 Spruce St Suite 10.103, St. Louis, MO 63103
Email:
stlouis@sba.govWebsite:
http://sba.gov/mo/stlouisBioSTL
Since 2001, St. Louis nonprofit BioSTL has laid the foundation for the region's innovation economy with a comprehensive set of transformational programs that elevate St. Louis’ leadership in solving important world challenges in agriculture, medicine, health care, and other technology areas. BioSTL has introduced nationally-acclaimed initiatives in startup creation and investment, strategic business attraction, physical environment, entrepreneur support, seed and venture capital, a diverse and inclusive workforce, and public policy.
Address:
4340 Duncan Ave., St. Louis, MO 63110
Email:
info@biostl.orgWebsite:
https://www.biostl.orgWorld Trade Center St. Louis
From customized research and training, to hosting inbound and outbound delegations, World Trade Center St. Louis brings together a strong system of business and government agencies to support trade and investment and enhance St. Louis’ global connectivity.
Address:
120 South Central Ave., Suite 200, St. Louis, MO 63105
Email:
info@stlpartnership.comWebsite:
https://stlpartnership.com/world-trade-center-st-louis/Regional Business Council
The Regional Business Council (RBC) is composed of 100 of the region’s large companies who come together to tackle high-impact business, civic, and philanthropic initiatives for the betterment of the St. Louis region.
Address:
7701 Forsyth Blvd Suite 205, St. Louis, MO 63105
Email:
administrator@stlrbc.orgWebsite:
https://www.stlrbc.org/Missouri Partnership
Missouri Partnership is a public-private economic development organization focused on attracting new jobs and investment to the state and promoting Missouri’s business strengths since 2008.
Address:
120 S Central Ave #1275, St. Louis, MO 63105
Email:
subash@missouripartnership.comWebsite:
https://www.missouripartnership.comAscension Ventures
Ascension Ventures (AV) helps accelerate innovation through strategic investment in early to late-stage companies across three healthcare sectors: services, technology, and medtech/devices.
Address:
4600 Edmundson Road, St. Louis, MO 63134
Email:
info@ascensionventures.orgWebsite:
https://ascensionventures.org/Advantage Capital
Advantage Capital invests in growth-ready entrepreneurs and industries in undercapitalized areas – often in partnership with the public sector. They target job-generating small businesses – along with affordable housing developments and energy solutions – to grow local economies.
Address:
7733 Forsyth Blvd #1400, St. Louis, MO 63105
Email:
info@advantagecap.comWebsite:
https://www.advantagecap.com/Twain Financial Partners
Twain Financial Partners is a full-service specialty finance firm with $6 billion in assets under management providing a full range of capital needs to real estate and renewable energy developments throughout the United States.
Address:
2200 Washington Ave, St. Louis, MO 63103
Email:
matthew.badler@twainfinancial.comWebsite:
https://twainfinancial.com/St. Louis Economic Development Partnership
To encourage economic activity and job creation in the region, STL Partnership provides specialty loans to existing businesses or qualified startups in the City of St. Louis and St. Louis County. The Partnership provides low-interest, subordinated loans and can be an essential part of the capital stack to make business expansion a reality. Loan funds may be used for working capital needs and the purchase of inventory, equipment, machinery, real estate, and other fixed assets.
Address:
120 S Central Ave Suite 200, St. Louis, MO 63105
Email:
info@stlpartnership.comWebsite:
https://stlpartnership.com/who-we-are/our-teams/business-finance/specialty-loans/St. Louis Arch Angels
The St. Louis Arch Angels is a network of accredited investors who fund high-potential early-stage businesses across the St. Louis region.
Rivervest Venture Partners
RiverVest Venture Partners® is a leading venture capital firm building life science companies to address significant unmet needs of patients and deliver consistently strong results to investors.
Address:
101 S Hanley Rd #1850, St. Louis, MO 63105
Email:
info@rivervest.comWebsite:
https://rivervest.com/Lewis & Clark Capital
Lewis & Clark Capital is a family office predominantly focused on taking control positions in lower-middle market operating companies. Specific focus areas include Industrial Manufacturing and Distribution, Business Services, B2B Software, and Hospitality.
Address:
120 S Central Ave #1000, Clayton, MO 63105
Email:
info@laccapital.comWebsite:
https://www.lewisandclarkventures.com/iSelect Fund
iSelect invests in agtech, soil, and crop health solutions to meet surging global protein demand, improve the taste, nutrition, and affordability of food, boost farmer profitability, and increase environmental sustainability. In the health sector, they invest in data analysis and delivery technologies that enable early detection, intervention, prevention, and treatment of cardio-metabolic diseases. Companies must be in agtech or health to qualify for funding.
Address:
1401 S Brentwood Blvd, Brentwood, MO 63144
Email:
curious@iselectfund.comWebsite:
https://www.iselectfund.com/Cultivation Capital
Cultivation Capital is a venture capital firm that manages a family of funds focused on early-stage investing. Most initial investments are during a startup’s Seed or Series A phase, and initial checks range from $100k – $3.5M. Industries of focus include life sciences and health tech, software and IT, agriculture tech, and geospatial tech.
Address:
911 Washington Ave #801, St. Louis, MO 63101
Email:
info@cultivationcapital.comWebsite:
https://cultivationcapital.com/about/Enterprise Mobility
The Enterprise Mobility Ventures team is committed to supporting emerging transportation technologies, platforms and innovations designed to improve lives.
Address:
600 Corporate Park Dr, St. Louis, MO 63105
Email:
emv@em.comWebsite:
https://www.enterprisemobility.com/en/innovation-in-mobility/corporate-venture-capital.htmlCapital Innovators
Capital Innovators provides top-ranked accelerator programs, venture fund management, and corporate innovation. It manages private and corporate venture funds focused on technology, consumer products, and energy innovations. It comes with mentorship, connections, and coworking space, and offers a 12 week accelerator for geospatial intelligence companies.
Address:
4220 Duncan Ave, St. Louis, MO 63110
Email:
info@capitalinnovators.comWebsite:
https://capitalinnovators.com/BioGenerator Ventures
BioGenerator Ventures provides catalytic investments to life sciences companies. Investment from BioGenerator Ventures comes with the BioGenerator Labs engine of company-building resources. Companies must be in the bioscience field (human healthcare and agriculture) field for investment.
Address:
4340 Duncan Ave, St. Louis, MO 63110
Email:
info@biogeneratorventures.comWebsite:
https://www.biostl.org/contact/contact-info-and-formPurina Petcare Innovation Prize
Competition for startups in pet care industry. Winner can get up to $50,000 in addition to support programs, connections, and mentorship opportunities
The Yield Lab
The Yield Lab champions early stage agrifoodtechs across 4 regions - North America, Latin America, Asia Pacific, and Europe.
Address:
1100 Corporate Square Dr #227, St. Louis, MO 63132
Email:
thad@theyieldlab.comWebsite:
https://www.theyieldlab.com/SixThirty Ventures
SixThirty is a global venture capital firm that invests in early-stage companies at the intersection of health, wealth and privacy. Our unique platform brings startups and institutions together to collaborate, creating a force multiplier for both.
Address:
8182 Maryland Avenue Suite 1401, St. Louis, MO 63105
Email:
hello@sixthirty.coWebsite:
https://sixthirty.co/WEPOWER
WEPOWER activates and supports business and community leaders to take action to make St. Louis’s economy and education systems better. Nearly 500 WEPOWER alumni—business and community leaders—have achieved big wins that impact thousands of educators and children and scaled businesses that positively support our economy and create living wage jobs.
